Endocrine Abstracts

Introduction: The incidence of hospitalised and fatal traumatic brain injury(TBI) is 235/100 000 with an average mortality rate of 15/100 000. A meta-analysis from 19 studies showed a prevalence of hypopituitarism after TBI of 27.5%.Case report: We report case of 72-year-old man, who suffered traumatic brain injury in October 2021, sustaining multiple skull fractures, with traumatic subarachnoid haemorrhage and subsequent pneumocephalus. He underwent bur...

A 34-year-old lady attended clinic-requesting information on recombinant prolactin to assist with breast feeding as she was 32 weeks gestation with her third pregnancy having failed to lactate after her first two pregnancies.In 2003 she developed pre-eclampsia during her first pregnancy and required delivery by Ventouse extraction. She had a significant post-partum haemorrhage of 1200 mls with haemoglobin 7g/dl but no evidence of cardiovascular compromis...

Introduction: Primary hyperparathyroidism is the most common cause of hypercalcemia in the ambulatory setting. Once the diagnosis has been confirmed, imaging of the parathyroid glands is performed locally with a combination of ultrasound scan (USS) and sestamibi/single-photon emission computed tomography (SPECT CT) to localise a parathyroid adenoma prior to surgery.Method: Data was collected on patients undergoing parathyroid surge...

Introduction: Primary hyperparathyroidism is the most common cause of hypercalcemia in the ambulatory setting. Once the diagnosis has been confirmed, imaging of the parathyroid glands is performed locally with a combination of ultrasound scan (USS) and sestamibi/single-photon emission computed tomography (SPECT CT) to localise a parathyroid adenoma prior to surgery.Method: Data was collected on patients undergoing parathyroid surge...

Introduction: Complete androgen insensitivity syndrome (CAIS) is an X-linked genetic disorder characterised by normal female appearance, including external genitalia and the presence of 46XY karyotype. We report a case of CAIS, diagnosed in adulthood, and discuss ethical issues surrounding the disclosure of diagnosis and associated difficulties in further management.Case history: A 33-year-old Nigerian lady was referred to our endocrine service with Prim...

Insulinoma is a rare but potentially treatable cause of hypoglycaemia. We present a case where achieving a diagnosis of insulinoma was complicated by evidence of low serum insulin levels during documented biochemical hypoglycaemia.A 58 year old lady presented with weight gain and daily episodes of shaking, hot flushes and disorientation that were relieved by the ingestion of food. During symptomatic episodes home capillary blood glucose measurements sugg...

A 12-year-old girl presented with dizziness, palpitations, headaches and sweating associated with hypertension (170/100 mmHg) and tachycardia (180 beats per minute). Repeated urinary and serum catecholamines were initially unremarkable. Routine biochemical and haematological testing was normal as were serum gut peptides. The patient was commenced on phenoxybenzamine, nifedipine and propranolol. This improved her symptoms, and corrected her tachycardia and raised blood pressure...

Phaeochromocytoma is a catecholamine producing tumour arising from the adrenomedullary chromaffin cells. It produces hormones such as epinephrine, norepinephrine, catecholamine and dopamine. (1) There have been some case reports describing an association between Brown adipose tissue (BAT) accumulation due to catecholamine excess caused by a phaeochromocytoma. We present a similar case in this abstract. A 77 year old lady was referred to the community geriatricians with symptom...

A 67-year male presented to his GP with polydypsia, ployuria and bone pains. Routine blood tests showed hypercalcemia (corrected calcium 2.77 mmol/l). Patient was otherwise well. He had a history of ethanol abuse, hypertension and gout.Medications: Allopurinol, ramipril simvastatin and co-dydramol. Repeat blood tests after 4 weeks show a rising calcium of 3.24 mmol/l with intact PTH 33.6 pmol/l (<6.4). He was referred to our endocrinology department ...

We present a 52-year-old lady with type 2 diabetes mellitus, referred by her GP with poor glycaemic control. Her past medical history included haemochromatosis, undifferentiated connective tissue disorder, depression, hypothyroidism, pernicious anaemia and alcohol abuse. Relevant medications were metformin 1 g bd, novorapid 28 units tds, levemir 30 mg od and prednisolone 5 mg od. Her HbA1c was 8.1%, renal function and baseline pituitary function was normal. Following an admiss...